Student publications

Student publications

Journal Articles

Wood, R, C Morrow, CE Barry, WA Bryden, CJ Call, AJ Hickey, CE Rodes, TJ Scriba, J Blackburn, C Issarow, N Mulder, J Woodward, A Moosa, V Singh, V Mizrahi, and DF Warner. 2016. "Real-Time Investigation of Tuberculosis Transmission: Developing the Respiratory Aerosol Sampling Chamber (RASC)." PLOS ONE, 11 (1).

Crum, MA, JM Park, BT Sewell, and MJ Benedik. 2015. "C-terminal hybrid mutant of Bacillus pumilus cyanide dihydratase dramatically enhances thermal stability and pH tolerance by reinforcing oligomerization." Journal of Applied Microbiology, 118 (4): 881-889.

Crum, MA, JM Park, AE Mulelu, BT Sewell, and MJ Benedik. 2015. "Probing C-terminal interactions of the Pseudomonas stutzeri cyanide-degrading CynD protein." Applied Microbiology and Biotechnology, 99 (7): 3093-3102.

Woodward, JD and RA Wepf. 2014. "Macromolecular 3D SEM reconstruction strategies: Signal to noise ratio and resolution." Ultramicroscopy, 144, 43-49.

Ambele, MA, BT Sewell, FR Cummings, PJ Smith, and TJ Egan. 2013. "Synthetic hemozoin (beta-hematin) crystals nucleate at the surface of neutral lipid droplets that control their sizes." Crystal Growth & Design, 13 (10).

Weber, BW, SW Kimani, A Varsani, DA Cowan, R Hunter, GA Venter, JC Gumbart, and BT Sewell. 2013. "The mechanism of the amidases: mutating the glutamate adjacent to the catalytic triad inactivates the enzyme due to substrate mispositioning." Journal of Biological Chemistry, 288 (40): 28514-28523.

Baum, S, DS Williamson, T Sewell, and A Stolz. 2012. "Conversion of sterically demanding alpha,alpha-disubstituted phenylacetonitriles by the arylacetonitrilase from Pseudomonas fluorescens EBC191." Applied and Environmental Microbiology, 78 (1): 48-57.

Broadley, SG, JC Gumbart, BW Weber, MJ Marakalala, DJ Steenkamp, and BT Sewell. 2012. "A new crystal form of MshB from Mycobacterium tuberculosis with glycerol and acetate in the active site suggests the catalytic mechanism." Acta Crystallographica. Section D, Biological crystallography, 68 (Pt 11): 1450-1459.

Manole, V, P Laurinmaki, W Van Wyngaardt, CA Potgieter, IM Wright, GJ Venter, AA van Dijk, BT Sewell, and SJ Butcher. 2012. "Structural insight into African horsesickness virus infection." Journal of Virology, 86 (15): 7858-7866.

Twala, BV, BT Sewell, and J Jordaan. 2012. "Immobilisation and characterisation of biocatalytic co-factor recycling enzymes, glucose dehydrogenase and NADH oxidase, on aldehyde functional ReSyn™ polymer microspheres." Enzyme and Microbial Technology, 50 (6-7): 331-336.

Wang, L, JM Watermeyer, AE Mulelu, BT Sewell, and MJ Benedik. 2012. "Engineering pH-tolerant mutants of a cyanide dihydratase." Applied Microbiology and Biotechnology, 94 (1): 131-140.

Chan, KY, J Gumbart, R McGreevy, JM Watermeyer, BT Sewell, and K Schulten. 2011. "Symmetry-restrained flexible fitting for symmetric EM maps." Structure (London, England: 1993), 19 (9): 1211-1218.

Miller, JL, J Woodward, S Chen, M Jaffer, B Weber, K Nagasaki, Y Tomaru, R Wepf, A Roseman, A Varsani, and T Sewell. 2011. "Three-dimensional reconstruction of Heterocapsa circularisquama RNA virus by electron cryo-microscopy." Journal of General Virology, 92 (8): 1960-1970.

Nel, AJM, IM Tuffin, BT Sewell, and DA Cowan. 2011. "Unique aliphatic amidase from a psychrotrophic and haloalkaliphilic nesterenkonia isolate." Applied and Environmental Microbiology, 77 (11): 3696-3702.

van Rooyen, JM, VR Abratt, H Belrhali, and T Sewell. 2011. "Crystal structure of Type III glutamine synthetase: surprising reversal of the inter-ring interface." Structure (London, England: 1993), 19 (4): 471-483.

van Rooyen, J, H Belrhali, V Abratt, and BT Sewell. 2011. "Proteolysis of the type III glutamine synthetase from Bacteroides fragilis causes expedient crystal-packing rearrangements." Acta Crystallographica. Section F, Structural biology and crystallization communications, 67 (Pt 3): 358-363.

Achilonu, I, S Gildenhuys, L Fisher, J Burke, S Fanucchi, BT Sewell, M Fernandes, and HW Dirr. 2010. "The role of a topologically conserved isoleucine in glutathione transferase structure, stability and function." Acta Crystallographica. Section F, Structural biology and crystallization communications, 66 (Pt 7): 776-780.

Briddon, RW, DP Martin, BE Owor, L Donaldson, PG Markham, RS Greber, and A Varsani. 2010. "A novel species of mastrevirus (family Geminiviridae) isolated from Digitaria didactyla grass from Australia." Archives of Virology, 155 (9): 1529-1534.

Briddon, RW, J Heydarnejad, F Khosrowfar, H Massumi, DP Martin, and A Varsani. 2010. "Turnip curly top virus, a highly divergent geminivirus infecting turnip in Iran." Virus Research, 152 (1–2): 169-175.

Erdmann, JB, DN Shepherd, DP Martin, A Varsani, EP Rybicki, and H Jeske. 2010. "Replicative intermediates of maize streak virus found during leaf development." Journal of General Virology, 91 (4): 1077-1081.

Gildenhuys, S, M Dobreva, N Kinsley, Y Sayed, J Burke, S Pelly, GP Gordon, M Sayed, BT Sewell, and HW Dirr. 2010. "Arginine 15 stabilizes an S(N)Ar reaction transition state and the binding of anionic ligands at the active site of human glutathione transferase A1-1." Biophysical Chemistry, 146 (2-3): 118-125.

Joubert, MK, N Kinsley, A Capovilla, BT Sewell, MS Jaffer, and M Khati. 2010. "A modeled structure of an aptamer-gp120 complex provides insight into the mechanism of HIV-1 neutralization." Biochemistry, 49 (28): 5880-5890.

Lefeuvre, P, DP Martin, G Harkins, P Lemey, AJA Gray, S Meredith, F Lakay, A Monjane, J Lett, A Varsani, and J Heydarnejad. 2010. "The spread of tomato yellow leaf curl virus from the Middle East to the world." PLoS Pathog, 6 (10).

Mondy, WL, D Cameron, J-P Timmermans, N de Clerck, A Sasov, C Casteleyn, J Woodward, S Lai-Yuen, and LA Piegl. 2010. "The Basement Membrane: Key to the Reverse Engineering Biological Tissues." Computer-Aided Design and Applications, 7 (sup1): 1-18.

Opperman, DJ, BT Sewell, D Litthauer, MN Isupov, JA Littlechild, and E van Heerden. 2010. "Crystal structure of a thermostable old yellow enzyme from Thermus scotoductus SA-01." Biochemical and Biophysical Research Communications, 393 (3): 426-431.

Ortiz-Catedral, L, B Kurenbach, M Massaro, K McInnes, DH Brunton, ME Hauber, DP Martin, and A Varsani. 2010. "A new isolate of beak and feather disease virus from endemic wild red-fronted parakeets (Cyanoramphus novaezelandiae) in New Zealand." Archives of Virology, 155 (4): 613-620.

Petersen, LN, S Marineo, S Mandala, F Davids, BT Sewell, and RA Ingle. 2010. "The missing link in plant histidine biosynthesis: Arabidopsis myoinositol monophosphatase-like2 encodes a functional histidinol-phosphate phosphatase." Plant Physiology, 152 (3): 1186-1196.

Shepherd, DN, DP Martin, E van der Walt, K Dent, A Varsani, and EP Rybicki. 2010. "Maize streak virus: an old and complex 'emerging' pathogen." Molecular Plant Pathology, 11 (1): 1-12.

Tazehkand, SA, AH Pour, J Heydarnejad, A Varsani, and H Massumi. 2010. "Identification of phytoplasmas associated with cultivated and ornamental plants in Kerman Province, Iran." Journal of Phytopathology, 158 (11-12): 713-720.

van Rooyen, JM, VR Abratt, H Belrhali, and BT Sewell. 2010. "Crystallization of recombinant Bacteroides fragilis glutamine synthetase (GlnN) isolated using a novel and rapid purification protocol." Protein expression and purification, 74 (2): 211-216.

Varsani, A, GK de Villiers, GL Regnard, RR Bragg, K Kondiah, II Hitzeroth, and EP Rybicki. 2010. "A unique isolate of beak and feather disease virus isolated from budgerigars (Melopsittacus undulatus) in South Africa." Archives of Virology, 155 (3): 435-439.

Watermeyer, JM, WL Kroger, HG O Neill, BT Sewell, and ED Sturrock. 2010. "Characterization of domain-selective inhibitor binding in angiotensin-converting enzyme using a novel derivative of lisinopril." Biochemical Journal, 428 (1): 67-74.

Williamson, DS, KC Dent, BW Weber, A Varsani, J Frederick, RN Thuku, RA Cameron, JH van Heerden, DA Cowan, and BT Sewell. 2010. "Structural and biochemical characterization of a nitrilase from the thermophilic bacterium, Geobacillus pallidus RAPc8." Applied Microbiology and Biotechnology, 88 (1): 143-153.

Woodward, JD and BT Sewell. 2010. "Tomography of asymmetric bulk specimens imaged by scanning electron microscopy." Ultramicroscopy, 110 (2): 170-175.

Dent, KC, BW Weber, MJ Benedik, and BT Sewell. 2009. "The cyanide hydratase from Neurospora crassa forms a helix which has a dimeric repeat." Applied Microbiology and Biotechnology, 82 (2): 271-278.

Frouws, TD, HG Patterton, and BT Sewell. 2009. "Histone octamer helical tubes suggest that an internucleosomal four-helix bundle stabilizes the chromatin fiber." Biophysical Journal, 96 (8): 3363-3371.

Maina, John and Jeremy Woodward. 2009. "Three-dimensional serial section computer reconstruction of the arrangement of the structural components of the parabronchus of the Ostrich, Struthio camelus lung." Anatomical Record (Hoboken, N.J.: 2007), 292 (11): 1685-1698.

Thuku, RN, D Brady, MJ Benedik, and BT Sewell. 2009. "Microbial nitrilases: versatile, spiral forming, industrial enzymes." Journal of Applied Microbiology, 106 (3): 703-727.

Varsani, A, DN Shepherd, K Dent, AL Monjane, EP Rybicki, and DP Martin. 2009. "A highly divergent South African geminivirus species illuminates the ancient evolutionary history of this family." Virology Journal, 6.

Woodward, JD, R Wepf, and BT Sewell. 2009. "Three-dimensional reconstruction of biological macromolecular complexes from in-lens scanning electron micrographs." Journal of Microscopy, 234 (3): 287-292.

Basile, LJ, RC Wilson, and BT Sewell. 2008. "Genome mining of cyanide-degrading nitrilases from filamentous fungi." Applied Microbiology and Biotechnology, 80 (3): 427-435.

Castillo-Urquiza, GP, JEA Beserra, FP Bruckner, ATM Lima, A Varsani, P Alfenas-Zerbini, and FM Zerbini. 2008. "Six novel begomoviruses infecting tomato and associated weeds in Southeastern Brazil." Archives of Virology, 153 (10): 1985-1989.

Oluwafemi, S, A Varsani, AL Monjane, DN Shepherd, BE Owor, EP Rybicki, and DP Martin. 2008. "A new African streak virus species from Nigeria." Archives of Virology, 153 (7): 1407-1410.

Shepherd, DN, DP Martin, P Lefeuvre, AL Monjane, BE Owor, EP Rybicki, and A Varsani. 2008. "A protocol for the rapid isolation of full geminivirus genomes from dried plant tissue." Journal of Virological Methods, 149 (1): 97-102.

Shepherd, DN, A Varsani, OP Windram, P Lefeuvre, AL Monjane, BE Owor, and DP Martin. 2008. "Novel sugarcane streak and sugarcane streak Reunion mastreviruses from southern Africa and La Réunion." Archives of Virology, 153 (3): 605-609.

van Antwerpen, T, SA McFarlane, GF Buchanan, DN Shepherd, DP Martin, EP Rybicki, and A Varsani. 2008. "First report of Maize streak virus field infection of sugarcane in South Africa." Plant Disease, 92 (6): 982.

van der Walt, E, DP Martin, A Varsani, JE Polston, and EP Rybicki. 2008. "Experimental observations of rapid Maize streak virus evolution reveal a strand-specific nucleotide substitution bias." Virology Journal, 5 (1).

Varsani, A, S Oluwafemi, OP Windram, DN Shepherd, AL Monjane, BE Owor, EP Rybicki, P Lefeuvre, and DP Martin. 2008. "Panicum streak virus diversity is similar to that observed for maize streak virus." Archives of Virology, 153 (3): 601-604.

Varsani, A, DN Shepherd, AL Monjane, BE Owor, JB Erdmann, EP Rybicki, M Peterschmitt, RW Briddon, PG Markham, S Oluwafemi, OP Windram, P Lefeuvre, J Lett, and DP Martin. 2008. "Recombination, decreased host specificity and increased mobility may have driven the emergence of maize streak virus as an agricultural pathogen." Journal of General Virology, 89 (9): 2063-2074.

Watermeyer, JM, WL Kroger, HG O Neill, BT Sewell, and ED Sturrock. 2008. "Probing the basis of domain-dependent inhibition using novel ketone inhibitors of angiotensin-converting enzyme." Biochemistry, 47 (22): 5942-5950.

Windram, OP, B Weber, MA Jaffer, EP Rybicki, DN Shepherd, and A Varsani. 2008. "An investigation into the use of human papillomavirus type 16 virus-like particles as a delivery vector system for foreign proteins: N- and C-terminal fusion of GFP to the L1 and L2 capsid proteins." Archives of Virology, 153 (3): 585-589.

Woodward, JD, BW Weber, MP Scheffer, MJ Benedik, A Hoenger, and BT Sewell. 2008. "Helical structure of unidirectionally shadowed metal replicas of cyanide hydratase from Gloeocercospora sorghi." Journal of Structural Biology, 161 (2): 111-119.

Woodward, J. and J. Maina. 2008. "Study of the structure of the air and blood capillaries of the gas exchange tissue of the avian lung by serial section three-dimensional reconstruction." Journal of Microscopy, 230 (Pt 1): 84-93.

Bourne, PE. 2007. "Ten simple rules for making good oral presentations." PLoS Computational Biology, 3 (4).

Bredell, H, DP Martin, J van Harmelen, A Varsani, HW Sheppard, R Donovan, CM Gray, and C Williamson. 2007. "HIV type 1 subtype C gag and nef diversity in Southern Africa." AIDS Research and Human Retroviruses, 23 (3): 477-481.

Corradi, HR, I Chitapi, BT Sewell, D Georgiadis, V Dive, ED Sturrock, and KR Acharya. 2007. "The structure of testis angiotensin-converting enzyme in complex with the C domain-specific inhibitor RXPA380." Biochemistry, 46 (18): 5473-5478.

Danilov, SM, JM Watermeyer, IV Balyasnikova, K Gordon, EV Kugaevskaya, YE Elisseeva, RF Albrecht, and ED Sturrock. 2007. "Fine epitope mapping of monoclonal antibody 5F1 reveals anticatalytic activity toward the N domain of human angiotensin-converting enzyme." Biochemistry, 46 (31): 9019-9031.

Erren, TC and PE Bourne. 2007. "Ten simple rules for a good poster presentation." PLoS Computational Biology, 3 (5).

Hajduk, PJ and J Greer. 2007. "A decade of fragment-based drug design: strategic advances and lessons learned." Nature Reviews Drug Discovery, 6 (3): 211-219.

Hell, SW. 2007. "Far-field optical nanoscopy." Science (New York, N.Y.), 316 (5828): 1153-1158.

Jaiswal, JK and SM Simon. 2007. "Imaging single events at the cell membrane." Nature Chemical Biology, 3 (2): 92-98.

Kimani, SW, VB Agarkar, DA Cowan, MFR Sayed, and BT Sewell. 2007. "Structure of an aliphatic amidase from Geobacillus pallidus RAPc8." Acta Crystallographica. Section D, Biological Crystallography, 63 (Pt 10): 1048-1058.

Lefeuvre, P, DP Martin, M Hoareau, F Naze, H Delatte, M Thierry, A Varsani, N Becker, B Reynaud, and J-M Lett. 2007. "Begomovirus melting pot in the south-west Indian Ocean islands: molecular diversity and evolution through recombination." Journal of General Virology, 88 (Pt 12): 3458-3468.

Makhongela, HS, AE Glowacka, VB Agarkar, BT Sewell, B Weber, RA Cameron, DA Cowan, and SG Burton. 2007. "A novel thermostable nitrilase superfamily amidase from Geobacillus pallidus showing acyl transfer activity." Applied Microbiology and Biotechnology, 75 (4): 801-811.

Norlén, L, S Masich, KN Goldie, and A Hoenger. 2007. "Structural analysis of vimentin and keratin intermediate filaments by cryo-electron tomography." Experimental Cell Research, 313 (10): 2217-2227.

Owor, BE, DP Martin, DN Shepherd, Edema, AL Monjane, EP Rybicki, JA Thomson, and A Varsani. 2007. "Genetic analysis of maize streak virus isolates from Uganda reveals widespread distribution of a recombinant variant." Journal of General Virology, 88 (Pt 11): 3154-3165.

Owor, BE, DN Shepherd, NJ Taylor, R Edema, AL Monjane, JA Thomson, DP Martin, and A Varsani. 2007. "Successful application of FTA Classic Card technology and use of bacteriophage phi29 DNA polymerase for large-scale field sampling and cloning of complete maize streak virus genomes." Journal of Virological Methods, 140 (1-2): 100-105.

Papakyriakou, A, GA Spyroulias, ED Sturrock, E Manessi-Zoupa, and P Cordopatis. 2007. "Simulated interactions between angiotensin-converting enzyme and substrate gonadotropin-releasing hormone: novel insights into domain selectivity." Biochemistry, 46 (30): 8753-8765.

Riviere, G, A Michaud, HR Corradi, ED Sturrock, KR Acharya, V Cogez, J-P Bohin, D Vieau, and P Corvol. 2007. "Characterization of the first angiotensin-converting like enzyme in bacteria: Ancestor ACE is already active." Gene, 399 (1): 81-90.

Thuku, RN, BW Weber, A Varsani, and BT Sewell. 2007. "Post-translational cleavage of recombinantly expressed nitrilase from Rhodococcus rhodochrous J1 yields a stable, active helical form." FEBS Journal, 274 (8): 2099-2108.

Vicens, Q and PE Bourne. 2007. "Ten simple rules for a successful collaboration." PLoS Computational Biology, 3 (3).

Webber, D, AL Rodgers, and ED Sturrock. 2007. "Glycosylation of prothrombin fragment 1 governs calcium oxalate crystal nucleation and aggregation, but not crystal growth." Urological Research, 35 (6): 277-285.

AB, E, DJR Pugh, R Kaptein, R Boelens, and AMJJ Bonvin. 2006. "Direct use of unassigned resonances in NMR structure calculations with proxy residues." Journal of the American Chemical Society, 128 (23): 7566-7571.

Agarkar, VB, SW Kimani, DA Cowan, MFR Sayed, and BT Sewell. 2006. "The quaternary structure of the amidase from Geobacillus pallidus RAPc8 is revealed by its crystal packing." Acta crystallographica. Section F, Structural biology and crystallization communications, 62 (Pt 12): 1174-1178.

Bourne, PE and LM Chalupa. 2006. "Ten simple rules for getting grants." PLoS Computational Biology, 2 (2).

Bourne, PE and A Korngreen. 2006. "Ten simple rules for reviewers." PLoS Computational Biology, 2 (9).

Bourne, PE and I Friedberg. 2006. "Ten simple rules for selecting a postdoctoral position." PLoS Computational Biology, 2 (11).

Corradi, HR, AV Corrigall, E Boix, CG Mohan, ED Sturrock, PN Meissner, and KR Acharya. 2006. "Crystal structure of protoporphyrinogen oxidase from Myxococcus xanthus and its complex with the inhibitor acifluorfen." Journal of Biological Chemistry, 281 (50): 38625-38633.

Corradi, HR, SLU Schwager, AT Nchinda, ED Sturrock, and KR Acharya. 2006. "Crystal structure of the N domain of human somatic angiotensin I-converting enzyme provides a structural basis for domain-specific inhibitor design." Journal of Molecular Biology, 357 (3): 964-974.

Donnert, G, J Keller, R Medda, MA Andrei, SO Rizzoli, R Luhrmann, R Jahn, C Eggeling, and SW Hell. 2006. "Macromolecular-scale resolution in biological fluorescence microscopy." Proceedings of the National Academy of Sciences of the United States of America, 103 (31): 11440-11445.

Farias, SL, RA Sabatini, TC Sampaio, IY Hirata, MHS Cezari, MA Juliano, ED Sturrock, AK Carmona, and L Juliano. 2006. "Angiotensin I-converting enzyme inhibitor peptides derived from the endostatin-containing NC1 fragment of human collagen XVIII." Biological Chemistry, 387 (5): 611-616.

Geisbrecht, BV, S Bouyain, and M Pop. 2006. "An optimized system for expression and purification of secreted bacterial proteins." Protein Expression and Purification, 46 (1): 23-32.

Heath, L, E van der Walt, A Varsani, and DP Martin. 2006. "Recombination patterns in aphthoviruses mirror those found in other picornaviruses." Journal of Virology, 80 (23): 11827-11832.

Kittel, RJ, C Wichmann, TM Rasse, W Fouquet, M Schmidt, A Schmid, DA Wagh, C Pawlu, RR Kellner, KI Willig, SW Hell, E Buchner, M Heckmann, and SJ Sigrist. 2006. "Bruchpilot promotes active zone assembly, Ca2+ channel clustering, and vesicle release." Science (New York, N.Y.), 312 (5776): 1051-1054.

Koch, C and K Hepp. 2006. "Quantum mechanics in the brain." Nature, 440 (7084): 611.

Kohl, T, I Hitzeroth, D Stewart, A Varsani, VA Govan, ND Christensen, AL Williamson, and EP Rybicki. 2006. "Plant-produced cottontail rabbit papillomavirus L1 protein protects against tumor challenge: a proof-of-concept study." Clinical and Vaccine Immunology, 13 (8): 845-853.

Mannella, CA. 2006. "The relevance of mitochondrial membrane topology to mitochondrial function." Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1762 (2): 140-147.

Nchinda, AT, K Chibale, P Redelinghuys, and ED Sturrock. 2006. "Synthesis and molecular modeling of a lisinopril-tryptophan analogue inhibitor of angiotensin I-converting enzyme." Bioorganic & Medicinal Chemistry Letters, 16 (17): 4616-4619.

Pugh, DJR, E AB, A Faro, PT Lutya, E Hoffmann, and DJG Rees. 2006. "DWNN, a novel ubiquitin-like domain, implicates RBBP6 in mRNA processing and ubiquitin-like pathways." BMC Structural Biology, 6.

Redelinghuys, P, AT Nchinda, K Chibale, and ED Sturrock. 2006. "Novel ketomethylene inhibitors of angiotensin I-converting enzyme (ACE): inhibition and molecular modelling." Biological Chemistry, 387 (4): 461-466.

Rodgers, AL, PD Mensah, SL Schwager, and ED Sturrock. 2006. "Inhibition of calcium oxalate crystallization by commercial human serum albumin and human urinary albumin isolated from two different race groups: evidence for possible molecular differences." Urological Research, 34 (6): 373-380.

Shepherd, DN, DP Martin, A Varsani, JA Thomson, EP Rybicki, and HH Klump. 2006. "Restoration of native folding of single-stranded DNA sequences through reverse mutations: an indication of a new epigenetic mechanism." Archives of Biochemistry and Biophysics, 453 (1): 108-122.

Tastan Bishop, AO and T Sewell. 2006. "A new approach to possible substrate binding mechanisms for nitrile hydratase." Biochemical and Biophysical Research Communications, 343 (1): 319-325.

van Rooyen, JM, VR Abratt, and BT Sewell. 2006. "Three-dimensional structure of a type III glutamine synthetase by single-particle reconstruction." Journal of Molecular Biology, 361 (4): 796-810.

Varsani, A, AL Williamson, MA Jaffer, and EP Rybicki. 2006. "A deletion and point mutation study of the human papillomavirus type 16 major capsid gene." Virus Research, 122 (1-2): 154-163.

Varsani, A, E van der Walt, L Heath, EP Rybicki, AL Williamson, and DP Martin. 2006. "Evidence of ancient papillomavirus recombination." Journal of General Virology, 87 (Pt 9): 2527-2531.

Varsani, A, A-L Williamson, D Stewart, and EP Rybicki. 2006. "Transient expression of human papillomavirus type 16 L1 protein in Nicotiana benthamiana using an infectious tobamovirus vector." Virus Research, 120 (1-2): 91-96.

Watermeyer, JM, BT Sewell, SL Schwager, R Natesh, HR Corradi, KR Acharya, and ED Sturrock. 2006. "Structure of testis ACE glycosylation mutants and evidence for conserved domain movement." Biochemistry, 45 (42): 12654-12663.

Webber, D, CM Radcliffe, L Royle, G Tobiasen, AH Merry, AL Rodgers, ED Sturrock, MR Wormald, DJ Harvey, RA Dwek, and PM Rudd. 2006. "Sialylation of urinary prothrombin fragment 1 is implicated as a contributory factor in the risk of calcium oxalate kidney stone formation." FEBS Journal, 273 (13): 3024-3037.

Wen, Z and JQ Zheng. 2006. "Directional guidance of nerve growth cones." Current Opinion in Neurobiology, 16 (1): 52-58.

Willig, KI, SO Rizzoli, V Westphal, R Jahn, and SW Hell. 2006. "STED microscopy reveals that synaptotagmin remains clustered after synaptic vesicle exocytosis." Nature, 440 (7086): 935-939.

Woodman, ZL, SLU Schwager, P Redelinghuys, AJ Chubb, EL van der Merwe, MRW Ehlers, and ED Sturrock. 2006. "Homologous substitution of ACE C-domain regions with N-domain sequences: effect on processing, shedding, and catalytic properties." Biological Chemistry, 387 (8): 1043-1051.

Balyasnikova, IV, ZL Sun, YV Berestetskaya, AJ Chubb, RF Albrecht, ED Sturrock, and SM Danilov. 2005. "Monoclonal antibodies 1B3 and 5C8 as probes for monitoring the integrity of the C-terminal end of soluble angiotensin-converting enzyme." Hybridoma (2005), 24 (1): 14-26.

Bourne, PE. 2005. "Ten simple rules for getting published." PLoS Computational Biology, 1 (5).

Buck, CB, CD Thompson, YS Pang, DR Lowy, and JT Schiller. 2005. "Maturation of papillomavirus capsids." Journal of Virology, 79 (5): 2839-2846.

Gillespie, AS and E Elliott. 2005. "Comparative advantages of imidazole-sodium dodecyl sulfate-zinc reverse staining in polyacrylamide gels." Analytical Biochemistry, 345 (1): 158-160.

Jandhyala, DM, RC Willson, BT Sewell, and MJ Benedik. 2005. "Comparison of cyanide-degrading nitrilases." Applied Microbiology and Biotechnology, 68 (3): 327-335.

Kuhnert, DC, Y Sayed, S Mosebi, M Sayed, BT Sewell, and HW Dirr. 2005. "Tertiary interactions stabilise the C-terminal region of human glutathione transferase A1-1: a crystallographic and calorimetric study." Journal of Molecular Biology, 349 (4): 825-838.

Lagerholm, BC, GE Weinreb, K Jacobson, and NL Thompson. 2005. "Detecting microdomains in intact cell membranes." Annual Review of Physical Chemistry, 56, 309-336.

Lei, J and J Frank. 2005. "Automated acquisition of cryo-electron micrographs for single particle reconstruction on an FEI Tecnai electron microscope." Journal of Structural Biology, 150 (1): 69-80.

Lucvic, V, F Forster, and W Baumeister. 2005. "Structural studies by electron tomography: from cells to molecules." Annual Review of Biochemistry, 74, 833-865.

Marsh, BJ. 2005. "Lessons from tomographic studies of the mammalian Golgi." Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1744 (3): 273-292.

Nagasaki, K, Y Shirai, Y Takao, H Mizumoto, K Nishida, and Y Tomaru. 2005. "Comparison of genome sequences of single-stranded RNA viruses infecting the bivalve-killing dinoflagellate Heterocapsa circularisquama." Applied and Environmental Microbiology, 71 (12): 8888-8894. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1317472/.

Onyemata, J, M Meyer, JM McKenzie, DJG Rees, and DJR Pugh. 2005. "Investigation of the binding of ceramide and palmitoyl-CoA to murine t-ACBP using heteronuclear NMR spectroscopy." South African Journal of Science, 101 (9-10): 430-434.

Pugh, DJR. 2005. "Biomolecular NMR spectroscopy in South Africa : the first five years." South African Journal of Science, 101 (9-10): 421-429.

Redelinghuys, P, AT Nchinda, and ED Sturrock. 2005. "Development of domain-selective angiotensin I-converting enzyme inhibitors." Annals of the New York Academy of Sciences, 1056, 160-175.

Sewell, BT, RN Thuku, X Zhang, and MJ Benedik. 2005. "Oligomeric structure of nitrilases: effect of mutating interfacial residues on activity." Annals of the New York Academy of Sciences, 1056, 153-159.

Woodman, ZL, SLU Schwager, P Redelinghuys, AK Carmona, MRW Ehlers, and ED Sturrock. 2005. "The N domain of somatic angiotensin-converting enzyme negatively regulates ectodomain shedding and catalytic activity." Biochemical Journal, 389 (Pt 3): 739-744.

Woodward, JD and JN Maina. 2005. "A 3D digital reconstruction of the components of the gas exchange tissue of the lung of the muscovy duck, Cairina moschata." Journal of Anatomy, 206 (5): 477-492.

Bersanetti, PA, MCC Andrade, DE Casarini, MA Juliano, AT Nchinda, ED Sturrock, L Juliano, and AK Carmona. 2004. "Positional-scanning combinatorial libraries of fluorescence resonance energy transfer peptides for defining substrate specificity of the angiotensin I-converting enzyme and development of selective C-domain substrates." Biochemistry, 43 (50): 15729-15736.

Bourne, PE, KJ Addess, WF Bluhm, L Chen, N Deshpande, Z Feng, W Fleri, R Green, JC Merino-Ott, W Townsend-Merino, H Weissig, J Westbrook, and HM Berman. 2004. "The distribution and query systems of the RCSB Protein Data Bank." Nucleic Acids Research, 32 (Database issue).

Chubb, AH, SLU Schwager, E van der Merwe, MRW Ehlers, and ED Sturrock. 2004. "Deletion of the cytoplasmic domain increases basal shedding of angiotensin-converting enzyme." Biochemical and Biophysical Research Communications, 314 (4): 971-975.

DePristo, MA, PIW de Bakker, and TL Blundell. 2004. "Heterogeneity and inaccuracy in protein structures solved by X-ray crystallography." Structure (London, England: 1993), 12 (5): 831-838.

Golub, T, S Wacha, and P Caroni. 2004. "Spatial and temporal control of signaling through lipid rafts." Current Opinion in Neurobiology, 14 (5): 542-550.

Hameroff, SR. 2004. "A new theory of the origin of cancer: quantum coherent entanglement, centrioles, mitosis, and differentiation." Biosystems, 77 (1-3): 119-136.

Marsh, BJ, N Volkmann, JR McIntosh, and KE Howell. 2004. "Direct continuities between cisternae at different levels of the Golgi complex in glucose-stimulated mouse islet beta cells." Proceedings of the National Academy of Sciences of the United States of America, 101 (15): 5565-5570.

Natesh, R, SLU Schwager, HR Evans, ED Sturrock, and KR Acharya. 2004. "Structural details on the binding of antihypertensive drugs captopril and enalaprilat to human testicular angiotensin I-converting enzyme." Biochemistry, 43 (27): 8718-8724.

Patwardhan, A, D Paul, HA AL-Khayat, and EP Morris. 2004. "A measure for the angle between projections based on the extent of correlation between corresponding central sections." Journal of Molecular Biology, 344 (3): 707-724.

Plaisier, JR, RI Koning, HK Koerten, M van Heel, and JP Abrahams. 2004. "TYSON: Robust searching, sorting, and selecting of single particles in electron micrographs." Journal of Structural Biology, 145, 76-83.

Rath, BK and J Frank. 2004. "Fast automatic particle picking from cryo-electron micrographs using a locally normalized cross-correlation function: a case study." Journal of Structural Biology, 145 (1-2): 84-90.

Roseman, AM. 2004. "FindEM - a fast, efficient program for automatic selection of particles from electron micrographs." Journal of Structural Biology, 145 (1-2): 91-99.

Sewell, BT, RB Best, S Baum, AM Roseman, GW Farr, AL Horwich, and HR Saibil. 2004. "A mutant chaperonin with rearranged inter-ring electrostatic contacts and temperature-sensitive dissociation." Nature Structural & Molecular Biology, 11 (11): 1128-1133.

Sturrock, ED, R Natesh, JM van Rooyen, and KR Acharya. 2004. "Structure of angiotensin I-converting enzyme." Cellular and Molecular Life Sciences, 61 (21): 2677-2686.

Sturrock, ED, R Natesh, JM van Rooyen, and KR Acharya. 2004. "What's new in the renin-angiotensin system?" Cellular and Molecular Life Sciences, 61 (21): 2677-2686.

Tama, F, O Miyashita, and CL Brooks. 2004. "Flexible multi-scale fitting of atomic structures into low-resolution electron density maps with elastic network normal mode analysis." Journal of Molecular Biology, 337 (4): 985-999.

Thiel, KA. 2004. "Structure-aided drug design's next generation." Nature Biotechnology, 22 (5): 513-519.

Tsekoa, TL, MF Sayed, RA Cameron, BT Sewell, and DA Cowan. 2004. "Purification, crystallization and preliminary X-ray diffraction analysis of thermostable nitrile hydratase." South African Journal of Science, 100 (9-10): 488-491.

White, HE, HR Saibil, A Ignatiou, and EV Orlova. 2004. "Recognition and separation of single particles with size variation by statistical analysis of their images." Journal of Molecular Biology, 336 (2): 453-460.

Zhu, Y, B Carragher, RM Glaeser, D Fellmann, C Bajaj, M Bern, F Mouche, F de Haas, RJ Hall, DJ Kriegman, SJ Ludtke, SP Mallick, PA Penczek, AM Roseman, FJ Sigworth, N Volkmann, and CS Potter. 2004. "Automatic particle selection: results of a comparative study." Journal of Structural Biology, 145 (1-2): 3-14.

Acharya, KR, ED Sturrock, JF Riordan, and MRW Ehlers. 2003. "ACE revisited: a new target for structure-based drug design." Nature Reviews. Drug Discovery, 2 (11): 891-902.

Baker, ML, W Jiang, BR Bowman, Z Hong Zhou, FA Quiocho, FJ Rixon, and W Chiu. 2003. "Architecture of the herpes simplex virus major capsid protein derived from structural bioinformatics." Journal of Molecular Biology, 331 (2): 447-456.

Chacon, P, F Tama, and W Wriggers. 2003. "Mega-dalton biomolecular motion captured from electron microscopy reconstructions." Journal of Molecular Biology, 326 (2): 485-492.

Flower, RJ. 2003. "The development of COX2 inhibitors." Nature Reviews Drug Discovery, 2 (3): 179-191.

Gordon, K, P Redelinghuys, SLU Schwager, MRW Ehlers, AC Papageorgiou, R Natesh, KR Acharya, and ED Sturrock. 2003. "Deglycosylation, processing and crystallization of human testis angiotensin-converting enzyme." The Biochemical journal, 371 (Pt 2): 437-442.

Guy, JL, RM Jackson, KR Acharya, ED Sturrock, NM Hooper, and AJ Turner. 2003. "Angiotensin-converting enzyme-2 (ACE2): comparative modeling of the active site, specificity requirements, and chloride dependence." Biochemistry, 42 (45): 13185-13192.

Heymann, JB, N Cheng, WW Newcomb, BL Trus, JC Brown, and AC Steven. 2003. "Dynamics of herpes simplex virus capsid maturation visualized by time-lapse cryo-electron microscopy." Nature Structural & Molecular Biology, 10 (5): 334-341.

Jandhyala, D, M Berman, PR Meyers, BT Sewell, RC Willson, and MJ Benedik. 2003. "CynD, the cyanide dihydratase from Bacillus pumilus: gene cloning and structural studies." Applied and Environmental Microbiology, 39 (8): 4794-4805.

Kuo, A, JM Gulbis, JF Antcliff, T Rahman, ED Lowe, J Zimmer, J Cuthbertson, FM Ashcroft, T Ezaki, and DA Doyle. 2003. "Crystal structure of the potassium channel KirBac1.1 in the closed state." Science, 300 (5627): 1922-1926.

Lanyi, JK and B Schobert. 2003. "Mechanism of proton transport in Bacteriorhodopsin from crystallographic structures of the K, L, M1, M2, and M2' intermediates of the photocycle." Journal of Molecular Biology, 328 (2): 439-450.

Munro, S. 2003. "Lipid rafts: elusive or illusive?" Cell, 115 (4): 377-388.

Natesh, R, SLU Schwager, ED Sturrock, and KR Acharya. 2003. "Crystal structure of the human angiotensin-converting enzyme-lisinopril complex." Nature, 421 (6922): 551-554.

Richmond, TJ and CA Davey. 2003. "The structure of DNA in the nucleosome core." Nature, 423 (6936): 145-150.

Roseman, AM. 2003. "Particle finding in electron micrographs using a fast local correlation algorithm." Ultramicroscopy, 94 (3-4): 225-236.

Rosenthal, PB and R Henderson. 2003. "Optimal determination of particle orientation, absolute hand, and contrast loss in single-particle electron cryomicroscopy." Journal of Molecular Biology, 333 (4): 721-745.

Schobert, B, LS Brown, and JK Lanyi. 2003. "Crystallographic structures of the M and N intermediates of Bacteriorhodopsin: assembly of a hydrogen-bonded chain of water molecules between Asp-96 and the retinal Schiff base." Journal of Molecular Biology, 330 (3): 553-570.

Sewell, BT, MN Berman, PR Meyers, D Jandhyala, and MJ Benedik. 2003. "The cyanide degrading nitrilase from Pseudomonas stutzeri AK61 is a two-fold symmetric, 14-subunit spiral." Structure (London, England: 1993), 11 (11): 1413-1422.

Smith, SA, R Sreenivasan, G Krishnasamy, KW Judge, KH Murthy, JS Arjunwadkar, DR Pugh, and GJ Kotwal. 2003. "Mapping of regions within the vaccinia virus complement control protein involved in dose-dependent binding to key complement components and heparin using surface plasmon resonance." Biochimica et Biophysica Acta, 1650 (1-2): 30-39.

Varsani, A, A-l Williamson, D de Villiers, I Becker, ND Christensen, and EP Rybicki. 2003. "Chimeric human papillomavirus type 16 (HPV-16) L1 particles presenting the common neutralizing epitope for the L2 minor capsid protein of HPV-6 and HPV-16." Journal of Virology, 77 (15): 8386-8393.

Varsani, A, A-L Williamson, RC Rose, M Jaffer, and EP Rybicki. 2003. "Expression of human papillomavirus type 16 major capsid protein in transgenic Nicotiana tabacum cv. Xanthi." Archives of Virology, 148 (9): 1771-1786.

Webber, D, AL Rodgers, and ED Sturrock. 2003. "Selective inclusion of proteins into urinary calcium oxalate crystals: comparison between stone-prone and stone-free population groups." Journal of Crystal Growth, 259 (1): 179-189.

Westbrook, J, Z Feng, L Chen, H Yang, and HM Berman. 2003. "The Protein Data Bank and structural genomics." Nucleic Acids Research, 31 (1): 489-491.

Wu, Xiongwu, Jacqueline Milne, Mario Borgnia, Alexey Rostapshov, Sriram Subramaniam, and Bernard Brooks. 2003. "A core-weighted fitting method for docking atomic structures into low-resolution maps: application to cryo-electron microscopy." Journal of Structural Biology, 141 (1): 63-76.

Carrio, MM and A Villaverde. 2002. "Construction and deconstruction of bacterial inclusion bodies." Journal of Biotechnology, 96 (1): 3-12.

Chacon, P and W Wriggers. 2002. "Multi-resolution contour-based fitting of macromolecular structures." Journal of Molecular Biology, 317 (3): 375-384.

Egan, TJ, JM Combrinck, J Egan, GR Hearne, HM Marques, S Ntenteni, BT Sewell, PJ Smith, D Taylor, DA van Schalkwyk, and JC Walden. 2002. "Fate of haem iron in the malaria parasite Plasmodium falciparum." Biochemical Journal, 362 (Pt 2): 343-347.

Frey, TG, CW Renken, and GA Perkins. 2002. "Insight into mitochondrial structure and function from electron tomography." Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1555 (1-3): 196-203.

Greer, DS, JD Westbrook, and PE Bourne. 2002. "An ontology driven architecture for derived representations of macromolecular structure." Bioinformatics (Oxford, England), 18 (9): 1280-1281.

Hameroff, S, A Nip, M Porter, and J Tuszynski. 2002. "Conduction pathways in microtubules, biological quantum computation, and consciousness." Biosystems, 64 (1-3): 149-168.

Hickman, AB, DR Ronning, RM Kotin, and F Dyda. 2002. "Structural Unity among Viral Origin Binding Proteins: Crystal Structure of the Nuclease Domain of Adeno-Associated Virus Rep." Molecular Cell, 10 (2): 327-337. http://www.sciencedirect.com/science/article/pii/S1097276502005920.

Kirsch, R, MA Jaffer, BE Woodburne, T Sewell, SL Kelly, RE Kirsch, and EG Shephard. 2002. "Fibrinogen is degraded and internalized during incubation with neutrophils, and fibrinogen products localize to electron lucent vesicles." Biochemical Journal, 364 (Pt 2): 403-412.

Medalia, O, I Weber, AS Frangakis, D Nicastro, G Gerisch, and W Baumeister. 2002. "Macromolecular architecture in eukaryotic cells visualized by cryoelectron tomography." Science (New York, N.Y.), 298 (5596): 1209-1213.

Predescu, D, S Predescu, and AB Malik. 2002. "Transport of nitrated albumin across continuous vascular endothelium." Proceedings of the National Academy of Sciences of the United States of America, 99 (21): 13932-13937.

Smith, SA, G Krishnasamy, KHM Murthy, A Cooper, K Bromek, PN Barlow, and GJ Kotwal. 2002. "Vaccinia virus complement control protein is monomeric, and retains structural and functional integrity after exposure to adverse conditions." Biochimica et Biophysica Acta, 1598 (1-2): 55-64.

Tama, F, W Wriggers, and CL Brooks. 2002. "Exploring global distortions of biological macromolecules and assemblies from low-resolution structural information and elastic network theory." Journal of Molecular Biology, 321 (2): 297-305.

Toyoshima, C and H Nomura. 2002. "Structural changes in the calcium pump accompanying the dissociation of calcium." Nature, 418 (6898): 605-611.

Westbrook, J, Z Feng, S Jain, TN Bhat, N Thanki, V Ravichandran, GL Gilliland, W Bluhm, H Weissig, DS Greer, PE Bourne, and HM Berman. 2002. "The Protein Data Bank: unifying the archive." Nucleic Acids Research, 30 (1): 245-248.

Bhat, TN, P Bourne, Z Feng, G Gilliland, S Jain, V Ravichandran, B Schneider, K Schneider, N Thanki, H Weissig, J Westbrook, and HM Berman. 2001. "The PDB data uniformity project." Nucleic Acids Research, 29 (1): 214-218.

Carrio, MM and A Villaverde. 2001. "Protein aggregation as bacterial inclusion bodies is reversible." FEBS Letters, 489 (1): 29-33.

Charpilienne, A, M Nejmeddine, M Berois, N Parez, E Neumann, E Hewat, G Trugnan, and J Cohen. 2001. "Individual Rotavirus-like Particles Containing 120 Molecules of Fluorescent Protein Are Visible in Living Cells." Journal of Biological Chemistry, 276 (31): 29361-29367. http://www.jbc.org/content/276/31/29361.

Janner, A. 2001. "Introduction to a general crystallography." Acta Crystallographica Section A Foundations of Crystallography, 57 (Pt 4): 378-388.

Lutter, M, GA Perkins, and X Wang. 2001. "The pro-apoptotic Bcl-2 family member tBid localizes to mitochondrial contact sites." BMC cell biology, 2, 22.

Mannella, CA, DR Pfeiffer, PC Bradshaw, II Moraru, B Slepchenko, LM Loew, CE Hsieh, K Buttle, and M Marko. 2001. "Topology of the mitochondrial inner membrane: dynamics and bioenergetic implications." IUBMB life, 52 (3-5): 93-100.

Marsh, BJ, DN Mastronarde, KF Buttle, KE Howell, and JR McIntosh. 2001. "Organellar relationships in the Golgi region of the pancreatic beta cell line, HIT-T15, visualized by high resolution electron tomography." Proceedings of the National Academy of Sciences of the United States of America, 98 (5): 2399-2406.

McEwen, BF and M Marko. 2001. "The emergence of electron tomography as an important tool for investigating cellular ultrastructure." Journal of Histochemistry & Cytochemistry, 49 (5): 553-563.

Morais-Cabral, JH, Y Zhou, and R MacKinnon. 2001. "Energetic optimization of ion conduction rate by the K+ selectivity filter." Nature, 414 (6859): 37-42.

Murthy, KH, SA Smith, VK Ganesh, KW Judge, N Mullin, PN Barlow, CM Ogata, and GJ Kotwal. 2001. "Crystal structure of a complement control protein that regulates both pathways of complement activation and binds heparan sulfate proteoglycans." Cell, 104 (2): 301-311.

Nagata, T. 2001. "Three-dimensional high voltage electron microscopy of thick biological specimens." Micron (Oxford, England: 1993), 32 (4): 387-404.

Nicholson, WV and RM Glaeser. 2001. "Review: automatic particle detection in electron microscopy." Journal of Structural Biology, 133 (2-3): 90-101.

Smith, SA and GJ Kotwal. 2001. "Virokines: novel immunomodulatory agents." Expert Opinion on Biological Therapy, 1 (3): 343-357.

Spahn, CM, JS Kieft, RA Grassucci, PA Penczek, K Zhou, JA Doudna, and J Frank. 2001. "Hepatitis C virus IRES RNA-induced changes in the conformation of the 40s ribosomal subunit." Science, 291 (5510): 1959-1962.

Volkmann, N, D DeRosier, P Matsudaira, and D Hanein. 2001. "An atomic model of actin filaments cross-linked by fimbrin and its implications for bundle assembly and function." The Journal of Cell Biology, 153 (5): 947-956.

Wriggers, W and S Birmanns. 2001. "Using situs for flexible and rigid-body fitting of multiresolution single-molecule data." Journal of Structural Biology, 133 (2-3): 193-202.

Zhou, Y, JH Morais-Cabral, A Kaufman, and R MacKinnon. 2001. "Chemistry of ion coordination and hydration revealed by a K+ channel–Fab complex at 2.0?Angstrom resolution." Nature, 414 (6859): 43-48.

Berman, HM, J Westbrook, Z Feng, G Gilliland, TN Bhat, H Weissig, IN Shindyalov, and PE Bourne. 2000. "The Protein Data Bank." Nucleic Acids Research, 28 (1): 235-242.

Hess, MW, M Muller, PL Debbage, M Vetterlein, and M Pavelka. 2000. "Cryopreparation provides new insight into the effects of brefeldin A on the structure of the HepG2 Golgi apparatus." Journal of Structural Biology, 130 (1): 63-72.

Kotwal, GJ. 2000. "Poxviral mimicry of complement and chemokine system components: what's the end game?" Trends in Immunology, 21 (5): 242-248.

Perkins, GA and TG Frey. 2000. "Recent structural insight into mitochondria gained by microscopy." Micron (Oxford, England: 1993), 31 (1): 97-111.

Rossmann, MG. 2000. "Fitting atomic models into electron-microscopy maps." Acta Crystallographica Section D Biological Crystallography, 56 (10): 1341-1349.

Smith, SA, NP Mullin, J Parkinson, SN Shchelkunov, AV Totmenin, VN Loparev, R Srisatjaluk, DN Reynolds, KL Keeling, DE Justus, PN Barlow, and GJ Kotwal. 2000. "Conserved surface-exposed K/R-X-K/R motifs and net positive charge on poxvirus complement control proteins serve as putative heparin binding sites and contribute to inhibition of molecular interactions with human endothelial cells." Journal of Virology, 74 (12): 5659-5666.

Toyoshima, C, M Nakasako, H Nomura, and H Ogawa. 2000. "Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 Angstrom resolution." Nature, 405 (6787): 647-655.

van Heel, M, B Gowen, R Matadeen, EV Orlova, E Finn, T Pape, D Cohen, H Stark, R Schmidt, M Schatz, and A Patwardhan. 2000. "Single-particle electron cryo-microscopy: towards atomic resolution." Quarterly Reviews of Biophysics, 33 (04): 307-369.

Westbrook, JD and PE Bourne. 2000. "STAR/mmCIF: an ontology for macromolecular structure." Bioinformatics (Oxford, England), 16 (2): 159-168.

Baneyx, F. 1999. "Recombinant protein expression in Escherichia coli." Current Opinion in Biotechnology, 10 (5): 411-421.

Cereghino, GPL and JM Cregg. 1999. "Applications of yeast in biotechnology: protein production and genetic analysis." Current Opinion in Biotechnology, 10 (5): 422-427.

Luecke, H, B Schobert, H-T Richter, J-P Cartailler, and JK Lanyi. 1999. "Structural changes in Bacteriorhodopsin during ion transport at 2 Angstrom resolution." Science, 286 (5438): 255-260.

Luecke, H, B Schobert, HT Richter, JP Cartailler, and JK Lanyi. 1999. "Structure of bacteriorhodopsin at 1.55 Angstrom resolution." Journal of Molecular Biology, 291 (4): 899-911.

McIntosh, DB, DG Woolley, DH MacLennan, B Vilsen, and JP Andersen. 1999. "Interaction of nucleotides with Asp351 and the conserved phosphorylation loop of sarcoplasmic reticulum Ca2+-ATPase." Journal of Biological Chemistry, 274 (36): 25227-25236.

Roux, B and R MacKinnon. 1999. "The cavity and pore helices in the KcsA K+ channel: electrostatic stabilization of monovalent cations." Science, 285 (5424): 100-102.

Sowadski, JM, LF Epstein, L Lankiewicz, and R Karlsson. 1999. "Conformational diversity of catalytic cores of protein kinases." Pharmacology & Therapeutics, 82 (2–3): 157-164.

Volkmann, N and D Hanein. 1999. "Quantitative fitting of atomic models into observed densities derived by electron microscopy." Journal of Structural Biology, 125 (2-3): 176-184.

Wriggers, W, R Milligan, and J McCammon. 1999. "Situs: A package for docking crystal structures into low-resolution maps from electron microscopy." Journal of Structural Biology, 125 (2-3): 185-195.

Doyle, DA, JM Cabral, RA Pfuetzner, A Kuo, JM Gulbis, SL Cohen, BT Chait, and R MacKinnon. 1998. "The structure of the potassium channel: molecular basis of K+ conduction and selectivity." Science, 280 (5360): 69-77.

Feliu, JX, R Cubarsi, and A Villaverde. 1998. "Optimized release of recombinant proteins by ultrasonication of E. coli cells." Biotechnology and Bioengineering, 58 (5): 536-540.

Hoenger, A, S Sack, M Thormahlen, A Marx, J Muller, H Gross, and E Mandelkow. 1998. "Image reconstructions of microtubules decorated with monomeric and dimeric kinesins: comparison with x-ray structure and implications for motility." Journal of Cell Biology, 141 (2): 419-430.

Kubinyi, H. 1998. "Structure-based design of enzyme inhibitors and receptor ligands." Current Opinion in Drug Discovery and Development, 1 (1): 4-15.

Lawrence, M, P Pilling, V Epa, A Berry, A Ogunniyi, and J Paton. 1998. "The crystal structure of pneumococcal surface antigen PsaA reveals a metal-binding site and a novel structure for a putative ABC-type binding protein." Structure, 6 (12): 1553-1561.

Di Francesco, V, J Garnier, and PJ Munson. 1997. "Protein topology recognition from secondary structure sequences: application of the hidden markov models to the alpha class proteins1." Journal of Molecular Biology, 267 (2): 446-463.

Efimov, AV. 1997. "Structural trees for protein superfamilies." Proteins: Structure, Function, and Bioinformatics, 28 (2): 241-260.

Kolinski, A, J Skolnick, A Godzik, and W-P Hu. 1997. "A method for the prediction of surface "U"-turns and transglobular connections in small proteins." Proteins, 27, 290-308.

Nicolls, FC, G de Jager, and BT Sewell. 1997. "Use of a general imaging model to achieve predictive autofocus in the scanning electron microscope." Ultramicroscopy, 69 (1): 25-37.

Orlova, EV, P Dube, JR Harris, E Beckman, F Zemlin, J Markl, and M van Heel. 1997. "Structure of keyhole limpet hemocyanin type 1 (KLH1) at 15 A resolution by electron cryomicroscopy and angular reconstitution." Journal of Molecular Biology, 271 (3): 417-437.

Perkins, G, C Renken, ME Martone, SJ Young, M Ellisman, and T Frey. 1997. "Electron tomography of neuronal mitochondria: three-dimensional structure and organization of cristae and membrane contacts." Journal of Structural Biology, 119 (3): 260-272.

Tsukamoto, Y, K Takiguchi, K Satou, E Furuichi, T Takagi, and S Kuhara. 1997. "Application of a deductive database system to search for topological and similar three-dimensional structures in protein." Computer applications in the biosciences : CABIOS, 13 (2): 183-190.

Wiles, AP, G Shaw, J Bright, A Perczel, ID Campbell, and PN Barlow. 1997. "NMR studies of a viral protein that mimics the regulators of complement activation." Journal of Molecular Biology, 272 (2): 253-265.

Baker, TS and JE Johnson. 1996. "Low resolution meets high: towards a resolution continuum from cells to atoms." Current Opinion in Structural Biology, 6 (5): 585-594.

Finkelstein, AV and BA Reva. 1996. "Search for the most stable folds of protein chains: I. Application of a self-consistent molecular field theory to a problem of protein three-dimensional structure prediction." Protein Engineering, 9 (5): 387-397.

Gibrat, J-F, T Madej, and SJ Bryant. 1996. "Surprising similarities in structure comparison." Current Opinion in Structural Biology, 6 (3): 377-385.

Koch, I, T Lengauer, and E Wanke. 1996. "An algorithm for finding maximal common subtopologies in a set of protein structures." Journal of Computational Biology, 3 (2): 289-306.

McIntosh, DB, DG Woolley, B Vilsen, and JP Andersen. 1996. "Mutagenesis of segment 487Phe-Ser-Arg-Asp-Arg-Lys492 of sarcoplasmic reticulum Ca2+-ATPase produces pumps defective in ATP binding." Journal of Biological Chemistry, 271 (42): 25778-25789.

Reva, BA and AV Finkelstein. 1996. "Search for the most stable folds of protein chains: II. Computation of stable architectures of β-proteins using a self-consistent molecular field theory." Protein Engineering, 9 (5): 399-411.

Russell, RB, RR Copley, and GJ Barton. 1996. "Protein fold recognition by mapping predicted secondary structures." Journal of Molecular Biology, 259 (3): 349-365.

Zor, T and Z Selinger. 1996. "Linearization of the Bradford protein assay increases its sensitivity: theoretical and experimental studies." Analytical Biochemistry, 236 (2): 302-308.

Delpierre, GR and BT Sewell. 1995. "Designing for the real world: physical science courseware for South African schools." Spectrum, 33 (4): 18-20.

Flower, DR. 1995. "FOLD: Integrated analysis and display of protein secondary structure." Journal of Molecular Graphics, 13 (6): 377-384.

Hubbard, TJ and J Park. 1995. "Fold recognition and ab initio structure predictions using hidden markov models and β-strand pair potentials." Proteins: Structure, Function, and Bioinformatics, 23 (3): 398-402.

Nanopoulos, D. 1995. "Theory of brain function, quantum mechanics and superstrings." arXiv:hep-ph/9505374, http://arxiv.org/abs/hep-ph/9505374 (accessed 2014-04-03 15:12:14).

Parsons, S. 1995. "Hybrid models of uncertainty in protein topology prediction." Applied Artificial Intelligence, 9 (3): 335-351.

Parthasarathy, M, P Garcia-Lario, D de Martino, SR Pottasch, D Kilkenny, P Martinez, KC Sahu, BE Reddy, and BT Sewell. 1995. "Fading and variations in the spectrum of the central star of the very young planetary nebula SAO 244567 (Hen 1357)." Astronomy and Astrophysics, 300.

Artymiuk, PJ, JM Grindley, AR Poirrette, DW Rice, EC Ujah, and P Willett. 1994. "Identification of β-sheet motifs, of ψ-loops, and of patterns of amino acid residues in three-dimensional protein structures using a subgraph-isomorphism algorithm." Journal of Chemical Information and Computer Sciences, 34 (1): 54-62.

Bork, P, L Holm, and C Sander. 1994. "The immunoglobulin fold: structural classification, sequence patterns and common core." Journal of Molecular Biology, 242 (4): 309-320.

Flores, TP, DS Moss, and JM Thornton. 1994. "An algorithm for automatically generating protein topology cartoons." Protein Engineering, 7 (1): 31-37.

Flower, DR. 1994. "β-Sheet topology: A new system of nomenclature." FEBS Letters, 344 (2): 247-250.

Flower, DR. 1994. "Automating the identification and analysis of protein β-barrels." Protein Engineering, 7 (11): 1305-1310.

Grigoriev, IV, AA Mironov, and AB Rakhmaninova. 1994. "Interhelical contacts determining the architecture of alpha-helical globular proteins." Journal of Biomolecular Structure and Dynamics, 12 (3): 559-572.

King, RD, DA Clark, J Shirazi, and MJE Sternberg. 1994. "On the use of machine learning to identify topological rules in the packing of β-strands." Protein Engineering, 7 (11): 1295-1303.

Kotwal, GJ. 1994. "Purification of virokines using ultrafiltration." American Biotechnology Laboratory, 12 (10): 76-77.

Orengo, C. 1994. "Classification of protein folds." Current Opinion in Structural Biology, 4 (3): 429-440.

Sampogna, RV and B Honig. 1994. "Environmental effects on the protonation states of active site residues in bacteriorhodopsin." Biophysical Journal, 66 (5): 1341-1352.

Clark, DA, CJ Rawlings, J Shirazi, L-L Li, K Schuerman, M Reeve, and A Véron. 1993. "Solving large combinatorial problems in molecular biology using the elipsys parallel constraint logic programming system." The Computer Journal, 36 (8): 690-701.

Grindley, HM, PJ Artymiuk, DW Rice, and P Willett. 1993. "Identification of tertiary structure resemblance in proteins using a maximal common subgraph isomorphism algorithm." Journal of Molecular Biology, 229 (3): 707-721.

Hutchinson, EG and JM Thornton. 1993. "The Greek key motif: extraction, classification and analysis." Protein Engineering, 6 (3): 233-245.

Lerner, L and DA Horita. 1993. "Teaching high-resolution nuclear magnetic resonance to graduate students in biophysics." Biophysical Journal, 65 (6): 2692-2697.

Mezey, PG. 1993. "Topological shape analysis of chain molecules: An application of the GSTE principle." Journal of Mathematical Chemistry, 12 (1): 365-373.

Rayment, I, HM Holden, M Whittaker, CB Yohn, M Lorenz, KC Holmes, and RA Milligan. 1993. "Structure of the actin-myosin complex and its implications for muscle contraction." Science, 261 (5117): 58-65.

Smith, TJ, NH Olson, RH Cheng, H Liu, ES Chase, WM Lee, DM Leippe, AG Mosser, RR Rueckert, and TS Baker. 1993. "Structure of human rhinovirus complexed with Fab fragments from a neutralizing antibody." Journal of Virology, 67 (3): 1148-1158.

Koch, I, F Kaden, and J Selbig. 1992. "Analysis of protein sheet topologies by graph theoretical methods." Proteins: Structure, Function, and Bioinformatics, 12 (4): 314-323.

McKenzie, R, GJ Kotwal, B Moss, CH Hammer, and MM Frank. 1992. "Regulation of complement activity by vaccinia virus complement-control protein." Journal of Infectious Diseases, 166 (6): 1245-1250.

Sewell, BT and GR Delpierre. 1992. "Using computers to integrate, consolidate and improve biochemical education." Biochemical Education, 20 (1): 14-17.

Stirk, HJ, DN Woolfson, EG Hutchinson, and JM Thornton. 1992. "Depicting topology and handedness in jellyroll structures." FEBS Letters, 308 (1): 1-3.

van Heel, M, M Schatz, and E Orlova. 1992. "Correlation functions revisited." Ultramicroscopy, 46 (1-4): 307-316.

Clark, DA, J Shirazi, and CJ Rawlings. 1991. "Protein topology prediction through constraint-based search and the evaluation of topological folding rules." Protein Engineering, 4 (7): 751-760.

Kraulis, P.. 1991. "MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures." Journal of Applied Crystallography, 24 (5): 946-950.

van Heel, M. 1991. "A fast algorithm for transposing large multidimensional image data sets." Ultramicroscopy, 38 (1): 75-83.

Blundell, TL, JA Jenkins, BT Sewell, LH Pearl, JB Cooper, IJ Tickle, B Veerapandian, and SP Wood. 1990. "X-ray analyses of aspartic proteinases. The three-dimensional structure at 2.1 A resolution of endothiapepsin." Journal of Molecular Biology, 211 (4): 919-941.

Chothia, C and AV Finkelstein. 1990. "The classification and origins of protein folding patterns." Annual Review of Biochemistry, 59, 1007-1039.

Hutchinson, EG and JM Thornton. 1990. "HERA—A program to draw schematic diagrams of protein secondary structures." Proteins: Structure, Function, and Bioinformatics, 8 (3): 203-212.

Kotwal, GJ, SN Isaacs, R McKenzie, MM Frank, and B Moss. 1990. "Inhibition of the complement cascade by the major secretory protein of vaccinia virus." Science, 250 (4982): 827-830.

Mitchell, EM, PJ Artymiuk, DW Rice, and P Willett. 1990. "Use of techniques derived from graph theory to compare secondary structure motifs in proteins." Journal of Molecular Biology, 212 (1): 151-166.

Lawrence, MC, MA Jaffer, and BT Sewell. 1989. "The application of the maximum entropy method to electron microscopic tomography." Ultramicroscopy, 31 (3): 285-301.

von Holt, C, WF Brandt, HJ Greyling, GG Lindsey, JD Retief, JD Rodrigues, S Schwager, and BT Sewell. 1989. "Isolation and characterization of histones." Methods in Enzymology, 170, 431-523.

Greyling, HJ, BT Sewell, and C Von Holt. 1988. "The reconstitution of a hybrid histone octamer containing avian 110Cys-des-thio-histone H3 and sea-urchin 73Cys-histone H4." European Journal of Biochemistry, 171 (3): 721-726.

Kotwal, GJ and B Moss. 1988. "Analysis of a large cluster of nonessential genes deleted from a vaccinia virus terminal transposition mutant." Virology, 167 (2): 524-537.

Kotwal, GJ and B Moss. 1988. "Vaccinia virus encodes a secretory polypeptide structurally related to complement control proteins." Nature, 335 (6186): 176-178.

Landsman, D, BT Sewell, and C von Holt. 1988. "Aberrant DNase I digestion kinetics of nucleosomal core particles from sea urchin sperm." Biochemical and Biophysical Research Communications, 155 (1): 66-73.

Priestle, J.. 1988. "RIBBON: a stereo cartoon drawing program for proteins." Journal of Applied Crystallography, 21 (5): 572-576.

Wiechelman, KJ, RD Braun, and JD Fitzpatrick. 1988. "Investigation of the bicinchoninic acid protein assay: identification of the groups responsible for color formation." Analytical Biochemistry, 175 (1): 231-237.

Blum, H, H Beier, and HJ Gross. 1987. "Improved silver staining of plant proteins, RNA and DNA in polyacrylamide gels." Electrophoresis, 8 (2): 93-99.

Chirgadze, YN. 1987. "Classification of spatial motifs of the anti-parallel beta structure in globular proteins." Protein Engineering, 1 (3): 241.

Chirgadze, YN. 1987. "Deduction and systematic classification of spatial motifs of the antiparallel ? structure in globular proteins." Acta Crystallographica Section A Foundations of Crystallography, 43 (3): 405-417.

Retief, JD, bt Sewell, and C Von Holt. 1987. "Nucleosome cores assembled in vitro occupy two preferred frames flanking the histone H1 gene from Psammechinus miliaris." Biochemistry, 26 (14): 4449-4453.

van Heel, M. 1987. "Angular reconstitution: a posteriori assignment of projection directions for 3D reconstruction." Ultramicroscopy, 21 (2): 111-123.

Brandt, WF, BT Sewell, and C von Holt. 1986. "Mr determination of histones from their electrophoretic mobility in acidic urea gels in the absence of detergents." FEBS Letters, 194 (2): 273-277.

Greyling, HJ, JP Hapgood, BT Sewell, and C von Holt. 1986. "Covalent labelling of histones with aurothiomalate. Gold-labelled H2A-H2B dimers assemble to octamers, which form crystalline helical tubes." European Journal of Biochemistry, 161 (1): 133-138.

Harauz, G and M van Heel. 1986. "Exact filters for general geometry three dimensional reconstruction." Optik, 73 (4): 146-156.

van Heel, M. 1986. "Noise-limited three-dimensional reconstructions." Optik, 73 (2): 83-86.

van Heel, M and G Harauz. 1986. "Resolution criteria for three dimensional reconstruction." Optik, 73 (3): 119-122.

Compton, SJ and CG Jones. 1985. "Mechanism of dye response and interference in the Bradford protein assay." Analytical Biochemistry, 151 (2): 369-374.

Rawlings, CJ, WR Taylor, J Nyakairu, J Fox, and MJE Sternberg. 1985. "Reasoning about protein topology using the logic programming language PROLOG." Journal of Molecular Graphics, 3 (4): 151-157.

Sheridan, RP, JS Dixon, and R Venkataraghavan. 1985. "Generating plausible protein folds by secondary structure similarity." International Journal of Peptide and Protein Research, 25 (2): 132-143.

Smith, PK, RI Krohn, GT Hermanson, AK Mallia, FH Gartner, MD Provenzano, EK Fujimoto, NM Goeke, BJ Olson, and DC Klenk. 1985. "Measurement of protein using bicinchoninic acid." Analytical biochemistry, 150 (1): 76-85.

Retief, JD, BT Sewell, HJ Greyling, S Schwager, and C von Holt. 1984. "Probing with DNase I of nucleosomal core particles assembled in vitro in the presence of polyglutamic acid." FEBS letters, 167 (1): 170-175.

Sewell, BT, C Bouloukos, and C von Holt. 1984. "Formaldehyde and glutaraldehyde in the fixation of chromatin for electron microscopy." Journal of Microscopy, 136 (Pt 1): 103-112.

Chrambach, A and TM Jovin. 1983. "Selected buffer systems for moving boundary electrophoresis on gels at various pH values, presented in a simplified manner." Electrophoresis, 4 (3): 190-204.

Greyling, HJ, S Schwager, BT Sewell, and C von Holt. 1983. "The identity of conformational states of reconstituted and native histone octamers." European Journal of Biochemistry, 137 (1-2): 221-226.

Taylor, WR and JM Thornton. 1983. "Prediction of super-secondary structure in proteins." Nature, 301 (5900): 540-542.

Aebi, U, WE Fowler, and PR Smith. 1982. "Three-dimensional structure of proteins determined by electron microscopy." Ultramicroscopy, 8 (1-2): 191-206.

McLellan, T. 1982. "Electrophoresis buffers for polyacrylamide gels at various pH." Analytical Biochemistry, 126 (1): 94-99.

Sewell, BT. 1982. "A rapid lookup table method for trigonometric functions." Software: Practice and Experience, 12 (10): 885-887.

Read, SM and DH Northcote. 1981. "Minimization of variation in the response to different proteins of the Coomassie blue G dye-binding assay for protein." Analytical Biochemistry, 116 (1): 53-64.

Richardson, JS. 1981. "The anatomy and taxonomy of protein structure." Advances in Protein Chemistry, 34, 167-339.

van Heel, M and J Frank. 1981. "Use of multivariate statistics in analysing the images of biological macromolecules." Ultramicroscopy, 6 (2): 187-194.

Klug, A, D Rhodes, J Smith, JT Finch, and JO Thomas. 1980. "A low resolution structure for the histone core of the nucleosome." Nature, 287 (5782): 509-516.

Ptitsyn, OB and AV Finkelstein. 1980. "Similarities of protein topologies: evolutionary divergence, functional convergence or principles of folding?" Quarterly Reviews of Biophysics, 13 (3): 339-386.

Blundell, TL, BT Sewell, and AD McLachlan. 1979. "Four-fold structural repeat in the acid proteases.".

Nagano, K. 1977. "Logical analysis of the mechanism of protein folding. IV. Super-secondary structures." Journal of Molecular Biology, 109 (2): 235-250.

Richardson, JS. 1977. "β-Sheet topology and the relatedness of proteins." Nature, 268 (5620): 495-500.

Sternberg, MJ and JM Thornton. 1977. "On the conformation of proteins: the handedness of the connection between parallel beta-strands." Journal of Molecular Biology, 110 (2): 269-283.

Bensadoun, A and D Weinstein. 1976. "Assay of proteins in the presence of interfering materials." Analytical Biochemistry, 70 (1): 241-250.

Bradford, MM. 1976. "A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding." Analytical Biochemistry, 72 (1-2): 248-254.

Levitt, M and C Chothia. 1976. "Structural patterns in globular proteins." Nature, 261 (5561): 552-558.

Crowther, RA and A Klug. 1975. "Structural analysis of macromolecular assemblies by image reconstruction from electron micrographs." Annual Review of Biochemistry, 44 (1): 161-182.

Dulley, JR and PA Grieve. 1975. "A simple technique for eliminating interference by detergents in the Lowry method of protein determination." Analytical Biochemistry, 64 (1): 136-141.

Hartree, EF. 1972. "Determination of protein: a modification of the lowry method that gives a linear photometric response." Analytical Biochemistry, 48 (2): 422-427.

Crowther, RA, DJ de Rosier, and A. Klug. 1970. "The reconstruction of a three-dimensional structure from projections and its application to electron microscopy." Proceedings of the Royal Society of London. A. Mathematical and Physical Sciences, 317 (1530): 319-340.

Laemmli, UK. 1970. "Cleavage of structural proteins during the assembly of the head of bacteriophage T4." Nature, 227 (5259): 680-685.

Tanaka, S and S Naya. 1969. "A theory of X-Ray scattering by disordered polymer crystals." Journal of the Physical Society of Japan, 26 (4): 982-993.

Klug, A and DJ de Rosier. 1966. "Optical filtering of electron micrographs: reconstruction of one-sided images." Nature, 212 (5057): 29-32.

Ornstein, L and BJ Davis. 1964. "Disc electrophoresis-I: background and theory." Annals of the New York Academy of Sciences, 121 (2): 321-349.

Klug, A, FHC Crick, and HW Wyckoff. 1958. "Diffraction by helical structures." Acta Crystallographica, 11 (3): 199-213.

Cochran, W, FH Crick, and V Vand. 1952. "The structure of synthetic polypeptides. I. The transform of atoms on a helix." Acta Crystallographica, 5 (5): 581-586.

Lowry, OH, NJ Rosebrough, AL Farr, and RJ Randall. 1951. "Protein measurement with the Folin phenol reagent." Journal of Biological Chemistry, 193 (1): 265-275.

Conferences

Sewell, BT. 2009. "The Nitrilases: Versatile Helix formers." Paper presented at the Gordon Research Conference on Three-Dimensional Electron Microscopy. 2009.

Kinfe, HH, VP Chhiba, J Frederick, K Mathiba, and D Brady. 2008. "Application of stereoselective biocatalysts for the enantiomeric resolution of beta-hydroxynitriles." Paper presented at the Biotechnology for the Sustainability of Human Society. 12-17 October 2008. Dalian, China. J Biotech. 136 (Supplement): S392.

Thuku, RN and BT Sewell. 2007. "The helical structure of the nitrilase from Rhodococcus rhodochrous J1 following a truncation in its C-terminus." Paper presented at the SPIDER Workshop.

Abidemi, KM, NB Ndabambi, E AB, R Boelens, T Diercks, DJG Rees, and DJR Pugh. 2006. "Solution structure of the RING finger domain from the splicing-associated protein RbBP6 determined using heteronuclear Nuclear Magnetic Resonance (NMR) Spectroscopy." Paper presented at the 1st African Structural Biology Conference. 24-27 October 2006. Wilderness, South Africa.

Faro, A and DJR Pugh. 2006. "Characterization of the interaction between the p53 binding domain of the human RBBP6 protein and p53 using heteronuclear NMR." Paper presented at the 1st African Structural Biology Conference. 24-27 October 2006. Wilderness, South Africa.

Frederick, J, D Brady, and BT Sewell. 2006. "Enzymes: new tools for synthetic chemistry." Paper presented at the 1st African Structural Biology Conference. 24-27 October 2006. Wilderness, South Africa.

Kaunda, K, RA Atkinson, JC McKenzie, J Moolman-Smook, and DJR Pugh. 2006. "An investigation of protein-protein interaction involving cardiac Myosin Binding Protein C (cMyBP-C) using Nuclear Magnetic Resonance (NMR) spectroscopy." Paper presented at the 1st African Structural Biology Conference. 24-27 October 2006. Wilderness, South Africa.

Thuku, RN and BT Sewell. 2006. "The formation of helical oligomers in the nitrilase from Rhodococcus rhodochrous J1 following truncations in the C-terminal." Paper presented at the 1st African Structural Biology Conference. 24-27 October 2006. Wilderness, South Africa.

Woodward, JD, B Weber, M Scheffer, MJ Benedik, and BT Sewell. 2006. "Three-dimensional reconstruction of unidirectionally shadowed metal replicas of cyanide hydratase from Gloeocercospora sorghi." Paper presented at the 1st African Structural Biology Conference. 24-27 October 2006. Wilderness, South Africa.

Sewell, B. 2005. "Three dimensional electron microscopic imaging of chromatin." Paper presented at the SA Biochemical Society Ninth Congress. 2005. Wilderness, South Africa.

Thuku, RN and BT Sewell. 2005. "The quaternary structure of Rhodococcus rhodochrous J1 nitrilase as revealed by negative staining." Paper presented at the 44th Annual Meeting of the Microscopy Society of Southern Africa. 5–7 December 2005. Pietermaritzburg, South Africa. Proc Microsc Soc S Afr, 35: 31.

van Rooyen, JM, VR Abratt, and BT Sewell. 2005. "Three-dimensional structure of a type III glutamine synthetase by single-particle reconstruction." Paper presented at the 19th SASBMB Conference. 16-29 January 2005. Stellenbosch, South Africa. Proc S Afr Soc Biomol Molec Biol.

Varsani, A, MA Jaffer, A Williamson, and E Rybicki. 2002. "Deletion and point mutation products of the human papillomavirus type 16 major capsid gene." Paper presented at the 15th International Conference on Electron Microscopy. 103-104.

Sewell, B and M Jaffer. 2001. "Failure of a simple model to account for the iridescent colours of woodhoopoes." Paper presented at the Annual Meeting of the Electron Microscopy Society of South Africa. 2001. Johannesburg, South Africa. Proc Microsc Soc S Afr, 31: 82.

Buirski-Burger, N and BT Sewell. 1998. "Can computer based education save science education in South Africa." Paper presented at the Proc SAARMSE. 439-445.

Koch, I and T Lengauer. 1997. "Detection of distant structural similarities in a set of proteins using a fast graph-based method." Paper presented at the 5th International Conference on Intelligent Systems in Molecular Biology. 1997. Halkidiki, Greece. Proc Int Conf Intell Syst Mol Biol, Vol 5, pp. 167-178.

Nicolls, F, G de Jager, and BT Sewell. 1996. "A predictive autofocus algorithm for SEM." Paper presented at the Annual Meeting of the Microscopy Society of Southern Africa. 1996. Durban, South Africa. Proc Microsc Soc S Afr, 26: 5.

Jaffer, MA and BT Sewell. 1995. "Is a slow-scan CCD camera a viable alternative to film?" Paper presented at the Proc Electron Microsc Soc S Afr. 6.

Lipinski, MR, MD Durholtz, ME Waldron, Oosthuizen, J Erasmus, and BT Sewell. 1995. "The visualisation of growth increments." Paper presented at the Proc Electron Microsc Soc S Afr. 72.

Rost, B. 1995. "TOPITS: threading one-dimensional predictions into three-dimensional structures." Paper presented at the ISMB: International Conference on Intelligent Systems for Molecular Biology. Cambridge, UK. Proc Int Conf Intell Syst Mol Biol, Vol 3, pp 314-321.

Sewell, BT, VH Gartz, and HE Frimmel. 1995. "The technique of cathodoluminescence applied to Witwatersrand quartz using a Leica S440 and Oxford MonoCL." Paper presented at the Proc Electron Microsc Soc S Afr. 5.

Gerneke, DA and BT Sewell. 1994. "SEM and the digital paradigm - blessing or curse?" Paper presented at the Proc Electron Microsc Soc S Afr. 12.

Hubbard, TJP. 1994. "Use of β-strand interaction pseudo-potentials in protein structure prediction and modelling." Paper presented at the Twenty-Seventh Hawaii International Conference on System Sciences. 4-7 January 1994. Wailea, HI, USA. pp 336-344.

Knutsen, RD, BT Sewell, and DA Gerneke. 1994. "Electron backscatter diffraction analysis for microtexture determination." Paper presented at the Proc Electron Microsc Soc S Afr. 15.

Nicolls, FC, G de Jager, and BT Sewell. 1994. "Towards a predictive autofocus algorithm for SEM." Paper presented at the Annual Meeting of the Electron Microscopy Society of South Africa. 1994. Proc Electron Microsc Soc South Afr, 24: 11.

Clark, DA, CJ Rawlings, J Shirazi, A Veron, and M Reeve. 1993. "Protein topology prediction through parallel constraint logic programming." Paper presented at the ISMB: International Conference on Intelligent Systems for Molecular Biology. Bethesda, USA. Proc Int Conf Intell Syst Mol Biol, Vol 1, pp. 83-91.

Sewell, BT. 1993. "The three-dimensional structure of isolated chromatin fibres." Paper presented at the Proc Electron Microsc Soc S Afr. 43.

Graham, M, MA Jaffer, MF Calitz, and BT Sewell. 1992. "The diameter of chromatin fibres in sections of cell nuclei." Paper presented at the Proc Microsc Soc S Afr. 137-138.

Warren, R, C Von Holt, and BT Sewell. 1992. "Investigating the structure of material found in the Rancho La Brea Tar Pits, Los Angeles." Paper presented at the Proc Electron Microsc Soc S Afr. 19-20.

Jaffer, MA, M Graham, and BT Sewell. 1990. "Measurement of the diameters of chromatin fibres from chicken erythrocyte and sea urchin sperm." 185-186.

Jaffer, MA, M Graham, and BT Sewell. 1990. "The interpretation of stain density maps of chromatin fibres obtained by electron microscopic tomography." Paper presented at the Annual Meeting of the Electron Microscopy Society of Southern Africa. 1990. 151-152. Proc Electron Microsc Soc S Afr.

Sewell, B and MC Lawrence. 1986. "The structure of the chromatin fibre in sea urchin sperm." Paper presented at the Annual Meeting of the Electron Microscopy Society of SA Conference. 1986. Proc Electron Microsc Soc S Afr, 16: 49-50.

Lawson, T, B Sewell, and C Von Holt. 1984. "Measurement of nucleosome spacer lengths from dark field electron micrographs." Paper presented at the Annual Meeting of the Electron Microscopy Society of South Africa. 1984. Stellenbosch, South Africa. Proc Electron Microsc Soc S Afr, 14: 73-74.

Saffer, S and B Sewell. 1975. "A fibrous supporting structure in the human erythrocyte membrane." Paper presented at the Annual Meeting of the Electron Microscopy Society of South Africa. 1975. Proc Electron Microsc Soc South Afr, 5: 23-24.

Sewell, B. 1974. "A new theory for the structure of the human erythrocyte membrane." Paper presented at the Annual Meeting of the Electron Microscopy Society of South Africa. 1974. Proc Electron Microsc Soc S Afr, 4: 17-18.

Theses

Frederick, Joni. 2013. "Genetic characterization of Rhodococcus rhodochrous ATCC BAA-870 with emphasis on nitrile hydrolysing enzymes." Ph.D. University of Cape Town, South Africa.

Kimani, Serah. 2011. "Catalysis, substrate binding and specificity in the amidase from Nesterenkonia species." Ph.D. University of Cape Town, South Africa.

Woodward, JD. 2011. "The relationship between structure and specificity in the plant nitrilases." Ph.D. University of Cape Town, South Africa.

van Rooyen, Jason. 2010. "Crystal structure of the large type III glutamine synthetase from Bacteroides fragilis." Ph.D. University of Cape Town, South Africa.

Miller, Jennifer. 2008. "Three-dimensional reconstruction of Heterocapsa circularisquama RNA virus by cryo-electron microscopy." M.Sc with distinction. University of Cape Town, South Africa.

Chitapi, Itai. 2007. "Structural characterization of angiotensin-converting enzyme active site sub-sites." M.Sc (Structural Biology) cum laude.

Kimani, Serah. 2007. "The crystal structure of an aliphatic amidase from Geobacillus pallidus RAPc8." M.Sc (Structural Biology) with distinction.

Murungi, Edwin. 2007. "Purification and characterisation of Plasmodium falciparum Hypoxanthine phosphoribosyltransferase." M.Sc. University of the Western Cape, South Africa.

Adusei-Danso, Felix. 2006. "Systematic approach to protein crystallization (with emphasis on Vaccinia Complement Control Protein)." M.Sc. University of the Western Cape, South Africa.

Frouws, T. 2006. "Iterative helical real-space reconstruction of histone octamer tubular crystals and implications for the 30nm chromatin fibre." M.Sc cum laude. University of the Western Cape, South Africa.

Thuku, Robert Ndoria. 2006. "The structure of the nitrilase from Rhodococcus rhodochrous J1: Homology modeling and three-dimensional reconstruction." M.Sc cum laude. University of the Western Cape, South Africa.

Woodward, Jeremy. 2006. "The feasibility of high resolution, three-dimensional reconstruction of metal-coated surfaces in structural biology." M.Sc cum laude. University of the Western Cape, South Africa.

Tsekoa, Tsepo. 2005. "Structure, enzymology and genetic engineering of Bacillus sp. RAPc8 nitrile hydratase." Ph.D. University of the Western Cape, South Africa.

van Rooyen, Jason. 2004. "Three-dimensional structure of a type III glutamine synthetase by single particle reconstruction." M.Sc cum laude. University of the Western Cape, South Africa.